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. 2019 Jul 17;29(7):934–945. doi: 10.1089/thy.2018.0709

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© Julieta Fernandez-Ruocco et al. 2019; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 3. — Hypothyroidism differently modulated Ca²⁺ and K⁺ currents. (A) I_Ca-L traces recorded in ventricular myocytes isolated from control animals and from animals with primary and central hypothyroidism. Dashed lines represent the 0 current level. (B) Current–voltage relationship and maximum I_Ca-L amplitude at +10 mV showing a similar increase in I_Ca-L density in both central and primary hypothyroidism (n = 8–15 cells from at least three animals in each group; *p < 0.05). (C) Traces of I_to recorded in ventricular myocytes isolated from control animals and from animals with primary and central hypothyroidism. Dashed lines represent the 0 current level. (D) Current–voltage relationships and maximum I_to amplitude at +50 mV, showing that primary hypothyroidism reduced I_to density, whereas hypothyroidism of central origin had no effect on this current (n = 10–15 cells from at least three animals in each group; *p < 0.05).