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. 2019 Jul 17;29(7):979–992. doi: 10.1089/thy.2018.0555

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© Christian M. Schürch et al. 2019; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 1. — Human anaplastic thyroid carcinomas (ATCs) express phagocytosis signaling and immune checkpoint molecules and are heavily infiltrated by macrophages. Hematoxylin and eosin (H&E) staining and immunohistochemistry (IHC) for CD47, calreticulin (CALR), macrophage markers (CD68 and CD163), and checkpoint molecules (PD-1 and PD-L1) in ATCs. (A and B) Patient #8: epithelioid and sarcomatoid variant of ATC. CD47: 2+; CALR: 3+; CD68: 40% positive cells; CD163: 29% positive cells; PD-1: 5% positive cells; PD-L1: 70% positive cells. (C and D) Patient #14: epithelioid variant of ATC. CD47: 1+; CALR: 2+; CD68: 14% positive cells; CD163: 28% positive cells; PD-1: 10% positive cells; PD-L1: 70% positive cells. (E) IHC staining intensity of CD47 and CALR in ATCs, as analyzed by semi-quantitative microscopy. (F) Percentages of CD68⁺ cells and CD163⁺ cells in ATCs, as analyzed by automated quantification (QuPath). (G) Percentages of PD-1⁺ cells and PD-L1⁺ cells in all tumors, as analyzed by microscopy. Scale bars: 40 μm.