Table 1. Obtained PAM EC₅₀ Values for 1 and DS2 at Selected GABA_A Receptor Subtypes^a.

	EC50 (μM) (pEC50 0ESEM, n)			EC20 (μM)
	1b	DS2b	GABA	GABA
α1β2δ	3.68 (5.43 ± 0.055, 4)	2.97 (5.53 ± 0.13, 3)	6.71 (5.17 ± 0.087, 4)	1.6–2.0
α4β2δ	2.91 (5.54 ± 0.069, 3)	1.41 (5.85 ± 0.085, 3)	0.25 (6.61 ± 0.030, 3)	0.08
α6β2δ	2.25 (5.65 ± 0.0038, 3)	2.02 (5.69 ± 0.10, 3)	0.21 (6.68 ± 0.13, 3)	0.05
α6β2γ2s	no modulation (n = 3)	no modulation (n = 3)	0.50 (6.30 ± 0.091, 3)	0.1–0.2

^aGABA agonist EC₅₀ values are given for reference and GABA EC₂₀ used for PAM testing is also given. No modulation means no activity at 10 μM.

^bTested as PAMs in the presence of the stated GABA EC₂₀.