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1a enhances DOX efficacy. HeLa cells were treated with DOX in the presence or absence of 1a for 72 h, and cell viability was measured using the MTT. CI values are calculated. D1 and D2 are the concentrations of 1a and DOX used in the combination, and DLX,1 and DLX,2 are the concentrations of a single drug to produce the same effect.
