Scheme 1. Synthesis of Compound 1a: (i) BuLi, THF, n-Hexane, −40 to 0 °C, 6 h; BrCH₂CH₂Br, −78 to 20 °C, 14 h; (ii) 1H-Imidazole, CuI, K₂CO₃, l-Proline, DMF; (iii) Hydrogen Peroxide, Glacial Acetic Acid; and (iv) (Bromomethyl)benzene, CH₃CN; Methanol, NaI.