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. 2019 Apr 18;47(13):e74. doi: 10.1093/nar/gkz267

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — In vivo Bone healing evaluated by μCT. The frontal (A), sagittal (B) and top (C) views of μCT imaging. (D–F) Quantitative analysis of bone area, volume and density. We seeded the Bac-aS-iP/Bac-Cre-transduced (CRISPRai group, n = 6) or mock-transduced (Mock group, n = 6) rBMSC into gelatin scaffolds as in Figure 4, and implanted the cell/scaffold constructs into the critical-size (6 mm in diameter) calvarial bone defects in rats. At weeks 4 and 8, the rats were subjected to μCT scanning to obtain the nascent bone area, volume and density. The percentages of healing, as calculated by dividing the nascent bone area (or volume, density) within the defect by those in the original defect, are shown above the bars (D–F). ****P < 0.0001. *** P < 0.001. ** P < 0.01. *P < 0.05.