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. 2019 May 22;47(13):6826–6841. doi: 10.1093/nar/gkz441

Figure 3.

Figure 3.

Over-retained PCNA prevents MMR and also affects MMR-independent process(es). (A) Mutation rates of ELG1+ and elg1Δ in wild-type, msh3Δ and msh6Δ backgrounds at the lys2–10A locus. Fold increases over wild-type are shown above. The number in the brackets, fold changes over ELG1+ in each mutant background. Error bars, 95% confidence intervals. *, no overlapping of error bars; ns, overlapping of error bars. (B) Mutation rates of elg1Δ, pol30-D21K and pol30-M644G in MSH2+ and msh2Δ backgrounds at the lys2–10A locus. Fold increases over wild-type are shown above. The number in the brackets, fold changes over a single msh2Δ. Error bars, 95% confidence intervals. *, no overlapping of error bars; ns, overlapping of error bars. (C) Mutation rates of ELG1+ and elg1Δ in wild-type, msh2Δ, pol30-R14E and msh2Δ pol30-R14E backgrounds at the CAN1 locus. Fold increases over wild-type are shown above. The number in the brackets, fold changes over ELG1+ in each mutant background. Error bars, 95% confidence intervals. *, no overlapping of error bars; ns, overlapping of error bars.