Table 1. Catalysts Screened for the Synthesis of Benzoxazolea.
entry | catalyst | yieldb (%) |
---|---|---|
1 | HCl | 48 |
2 | H3PO4 | 45 |
3 | CF3COOH | 39 |
4 | MsOH | 43 |
5 | TsOH | 51 |
6 | AlCl3 | 55 |
7 | FeCl3 | 43 |
8 | CuCl2 | 45 |
9 | HfCl4 | 39 |
10 | Al2O3 | 31 |
11 | Fe2O3 | 29 |
12 | MgO | 23 |
13 | TiO2 | 28 |
14 | BAIL | 87 |
15 | TEOS | 0 |
16 | BAIL gel | 98 |
Reaction conditions: benzaldehyde (1.0 mmol), 2-aminophenol (1.0 mmol).
Isolated yield.