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. 2019 Jun 10;4(6):10070–10077. doi: 10.1021/acsomega.9b00140

Figure 2.

Figure 2

Esterase-triggered GSH depletion by B2C. (a) Mechanism of esterase-triggered GSH depletion through the formation of QM intermediates. (b) Depletion of GSH by B2C in the presence or absence of esterase. The concentration of GSH is 500 μM. (c) Comparison of the GSH-depleting ability of B2C with B1C and DBC. The concentrations of B2C, B1C, and DBC are 1 mM. Values are mean ± SD (n = 4). ***p < 0.001 relative to a group of esterase only. †††p < 0.001 relative to B1C. Level of GSH in (d) SW620 cells, (e) DU145 cells, and (f) A549 cells after B2C treatment. Values are mean ± SD (n = 4). ***p < 0.001 relative to a group of 0 μM.