Table1:

Suggestive level associations of SNP-insecticide interaction with sarcoidosis risk in AMASS study.

SNP	CHR	BP	MAF	Alleles (mino/maj)	Pmarginal	Pinteraction	PGEEjoint	Category	Interaction		Insecticide Exposure
											Unexposed		Exposed
									OR	95% CI	OR	95% CI	OR	95% CI
rs1347729	2	140323265	0.110	A/C	3.26*10−5	0.018	8.94*10−6	2	0.559	0.345 – 0.904	0.746	0.579 – 0.961	0.417	0.277 – 0.627
rs7660096	4	10903005	0.176	G/A	4.17*10−7	0.773	5.13*10−6	1	1.069	0.678 – 1.686	1.632	1.298 – 2.053	1.745	1.181 – 2.580
rs2904192	4	10904684	0.175	G/T	3.37*10−7	0.910	4.89*10−6	1	1.027	0.650 – 1.621	1.662	1.320 – 2.092	1.706	1.154 – 2.524
rs2227139*	6	32413459	0.478	G/A	1.26*10−6	0.053	1.21*10−6	1	1.561	0.994 – 2.451	1.445	1.141 – 1.829	2.256	1.539 – 3.305
rs9268668	6	32413889	0.427	C/A	3.84*10−6	0.053	3.41*10−6	1	1.522	0.995 – 2.327	1.378	1.107 – 1.715	2.097	1.460 – 3.011
rs3129890*	6	32414273	0.431	C/T	2.01*10−7	0.027	1.14*10−7	2	1.622	1.056 – 2.493	1.432	1.149 – 1.785	2.324	1.606 – 3.362
rs7180475	15	36701276	0.056	T/C	2.28*10−6	0.162	5.91*10−6	1	0.636	0.338 – 1.199	0.602	0.443 – 0.818	0.383	0.224 – 0.655

^*category 2 SNPs rs8084 (r² = 0.64), rs9268659 (r² = 0.64), rs2239802 (r² = 0.33), rs7196 (r² = 0.33) and rs7776297 (r² = 0.47) are in close linkage disequilibrium (LD) with rs3129890. Similarly, rs7192 (r² = 0.997), rs4935354 (r² = 0.998), rs7195 (r² = 1), rs2213586 (r² = 1), rs2213585 (r² = 1), rs2213584 (r² = 1) and rs3763327 (r² = 0.987) are in close LD with rs2227139.