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. 2019 Jul 16;10:1621. doi: 10.3389/fimmu.2019.01621

Figure 1.

Figure 1

NLRP3 inflammasome does not affect obesity-induced LV hypertrophy. WT, Nlrp3−/−, and Asc−/− (Pycard−/−) male mice were exposed to high fat diet (HFD; 60 cal% fat) or control diet for 52 weeks. (A) Comparison of bodyweight gain in mice on control or HFD during the 52 weeks [WT: Control, n = 12; HFD, n = 12, Nlrp3−/−: Control, n = 11; HFD, n = 12, and Asc−/− (Pycard−/−): Control, n = 10; HFD, n = 12]. (B) Left ventricle (LV) weight normalized to tibia length weeks [WT: Control, n = 11; HFD, n = 11, Nlrp3−/−: Control, n = 8; HFD, n = 8, and Asc−/− (Pycard−/−): Control, n = 10; HFD, n = 6]. (C) Representative images of wheat germ agglutinin (WGA) stained LV sections [WT: Control, n = 8; HFD, n = 9, Nlrp3−/−: Control, n = 7; HFD, n = 7, and Asc−/− (Pycard−/−): Control, n = 8; HFD, n = 5). Scale bar: 100 μm. (D) Quantification of cardiomyocyte cross-sectional surface area. Data are means ± SEM. *P < 0.05, **P < 0.01 vs. control diet as determined by two-way ANOVA and Tukey's multiple comparisons test. #P < 0.05 vs. NLRP3-HFD and ASC-HFD as determined by repeated measures two-way ANOVA and Tukey's multiple comparisons test.