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. 2019 Jul 16;10:1621. doi: 10.3389/fimmu.2019.01621

Figure 2.

Figure 2

Beneficial effect of NLRP3 and ASC deficiency on obesity-induced LV concentric remodeling and dysfunction. WT, Nlrp3−/−, and Asc−/− (Pycard−/−) male mice were exposed to a high fat diet (HFD; 60 cal% fat) or a control diet for 52 weeks. Cardiac structure and function was assessed by echocardiography. WT: Control, n = 6; HFD, n = 10, Nlrp3−/−: Control, n = 6; HFD, n = 7, and Asc−/− (Pycard−/−): Control, n = 6; HFD, n = 7, and cardiac magnetic resonance imaging [MRI; WT: Control, n = 6; HFD, n = 6, Nlrp3−/−: Control, n = 6; HFD, n = 6, and Asc−/− (Pycard−/−): Control, n = 6; HFD, n = 6]. (A) Left ventricular internal diameter at end diastole (LVIDd), (B) LV posterior wall thickness at end diastole (LVPWd), (C) interventricular septum thickness at end diastole (IVSd), (D) LV relative wall thickness (RWT), (E) longitudinal strain (MRI), and (F) early diastolic mitral annular velocity (e′ peak; MRI). Data are means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 vs. control diet. #P < 0.05 vs. WT HFD.