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. 2019 Jul 16;10:1621. doi: 10.3389/fimmu.2019.01621

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Copyright © 2019 Sokolova, Sjaastad, Louwe, Alfsnes, Aronsen, Zhang, Haugstad, Bendiksen, Øgaard, Bliksøen, Lien, Berge, Aukrust, Ranheim and Yndestad.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Obesity-induced hepatic steatosis is suppressed by NLRP3 and ASC deficiency. WT, Nlrp3^−/−, and Asc^−/− (Pycard^−/−) male mice were exposed to high fat diet (HFD; 60 cal% fat) or a control diet for 52 weeks and liver was extirpated. (A) Representative images of livers and hematoxylin and eosin staining from mice on HFD and Control diet. Scale bar: 100 μm. (B) Liver weights related to tibia length (TL). Hepatic levels of (C) cholesterol and (D) triglycerides. WT: Control, n = 10; HFD, n = 10, Nlrp3^−/−: Control, n = 7; HFD, n = 7, and Asc^−/−(Pycard^−/−): Control, n = 9; HFD, n = 5. Data are shown as mean ± SEM. ^**P < 0.01, ^***P < 0.001 vs. control diet; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 vs. WT-HFD as determined by two-way ANOVA and Tukey's multiple comparisons test.