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. 2019 Jul 16;10:1621. doi: 10.3389/fimmu.2019.01621

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Copyright © 2019 Sokolova, Sjaastad, Louwe, Alfsnes, Aronsen, Zhang, Haugstad, Bendiksen, Øgaard, Bliksøen, Lien, Berge, Aukrust, Ranheim and Yndestad.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Obesity-induced LV remodeling is not associated with cardiac fibrosis. WT, Nlrp3^−/−, and Asc^−/− (Pycard^−/−) male mice were exposed to high fat diet (HFD; 60 cal% fat) or control diet for 52 weeks and cardiac fibrosis was evaluated. (A) Representative images of picrosirius red stained left ventricle (LV) from a WT mouse on control diet and HFD. Scale bar: 500 μm. (B) Quantification of picrosirius red positive areas in LV. LV expression of (C) collagen I mRNA and (D) collagen III mRNA. WT: Control, n = 10; HFD, n = 10, Nlrp3^−/−: Control, n = 7; HFD, n = 7, and Asc^−/− (Pycard^−/−): Control, n = 7; HFD, n = 7. Data are shown as mean ± SEM. ^**P < 0.01 vs. control diet; ^#P < 0.05 vs. WT-HFD as determined by two-way ANOVA and Tukey's multiple comparisons test.