Table 3.
The role of liver-resident lymphocytes in liver diseases.
| Protective response | Liver diseases | Pathological response |
|---|---|---|
|
CD8+TRM (Producing IFN-γ, TNF-α, Granzyme, and Perforin) |
Viral infection (HBV, HCV, LCMV infection) |
Liver-resident NK (Expressing NKG2A and PD-L1 to suppress T cell function) |
|
Liver-resident NK (Producing IFN-γ, TNF-α, and GM-CSF) |
||
|
Liver-resident type I NKT (Producing IFN-γ) |
||
|
CD8+TRM (Producing IFN-γ and TNF-α) |
Parasite infection (L.infantum infection, Malaria infection) |
|
|
Liver-resident NK (Killing activated HSCs) |
Hepatic inflammatory diseases (Hepatitis, Liver fibrosis, Liver cirrhosis, NAFLD, ALD) |
Liver-resident ILC2s (Producing IL-5 and IL-13) |
|
Liver-resident ILC2s (Inhibiting TNF-α production) |
Liver-resident ILC3s (Producing IL-22 to recruit Th17 cells) |
|
|
Liver-resident ILC3s (Producing IL-22) |
Liver-resident
γδT (Producing IL-17) |
|
|
Liver-resident type II NKT (Antagonizing type I NKT) |
Liver-resident type I NKT (Producing IFN-γ and IL-13) |
|
|
CD8+TRM (Producing IFN-γ and TNF-α)Liver-resident NK (Producing IFN-γ and Granzyme) |
Hepatocellular carcinoma | |
|
Liver-resident type I NKT (Producing IFN-γ) |