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Inhibition of DfrB1 with monomeric inhibitor 31. (A) Inhibition, with Hill plot (inset). Values are given as the mean ± standard deviation for triplicate results. The Hill coefficient is 1.1 ± 0.4. (B) In silico reconstruction of 31 in the active site of DfrB1 based on the crystal structure PDB ID 6NXZ. Top: multiple poses adopted by 31 in the active site of DfrB1; only two DfrB1 protomers are shown in the 90° view. Bottom: a representative pose of 31 from a 90° view.
