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. 2019 Mar 4;4(3):4793–4803. doi: 10.1021/acsomega.8b03671

Table 3. Comparison With the Literature of In Vitro Release of VB12 Using Hydrogels.

article monomers VB12-loading concentration release of VB12 references
Boruah et al. CMC-g-poly(acrylic acid) and organophilic montmorillonite nanoclay composite 0.125 wt % in buffer solution of pH = 7.0 55 and 34% cumulative release in 10 h for pH 7.4 and 1.2 respectively (22)
Nath and Dolui CMC-g-poly(acrylic acid) and LDH 1.25 wt % in buffer solution of pH = 7.0 released in pH = 1.2 and 7.4. 59 and 45% cumulative release in 6 h for pH 7.4 and 1.2, respectively, for that without LDH. With LDH, 66 and 50% cumulative release in 6 h for pH 7.4 and 1.2 respectively (23)
Cao et al. xylan-type hemicellulose 0.5 mg mL–1 aqueous solution PBS buffer, with or without the presence of UV irradiation of 365 nm, at 37 ± 3 °C. Cumulative release is 89.3% (24)
present study CMC sodium salt and beechwood xylan 0.5 mg mL–1 aqueous solution 19–28% release in AGF, 80–88% release in AIF, and 93–98% release in PBS within 8 h at 37 °C. 93–99% release in consecutive physiological buffers within 10 h