Table 1. Plasmid DNA Relaxation Inhibition and Maximum Plasma Concentrations of Selected Fluoroquinolones.

	relaxation inhibition in purified systema
	Top2A (μg/mL)	Top2B (μg/mL)	maximum plasma concentrationsb (μg/mL)
gemifloxacin	24 (50 μM)	24 (50 μM)	1.61 ± 0.51
moxifloxacin			6.1 ± 1.3
levofloxacin			9.3 ± 1.6
ciprofloxacin	110 (300 μM)	110 (300 μM)	5.4
desethylene-ciprofloxacin	110 (300 μM)	74–110 (200–300 μM)	<0.81

^aLowest concentration with significant impact on relaxation.

^bConcentrations based upon the highest C_max values from package inserts;²⁹⁻³² statistical error data shown where provided.