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. 2019 Jun 25;4(6):11025–11031. doi: 10.1021/acsomega.9b01166

Scheme 1. Illustration of a DNA Origami-Assisted Electrochemical Biosensor for miRNA Detection.

Scheme 1

The cross-shaped DNA origami, containing preselected ssDNA probes, was immobilized on a gold electrode surface, via chitosan adsorption. MB molecules were used as redox indicators to show the differences before and after miRNA hybridization.