Table 1.
Pharmacokinetic parameters of curcumin after i.v. administration of curcumin solution and NSs at a dose of 10 mg/kg in rat (mean±SE, n=6)
| Parameter | TPGS-NS | Tween-NS | Curcumin solution |
|---|---|---|---|
| Kel (1/h) | 0.48±0.100 | 0.39±0.048 | 0.68±0.106 |
| t1/2 (h) | 1.45±0.180* | 1.94±0.292** | 1.11±0.168 |
| Cmax (ng/mL) | 1121.28±46.259* | 1311.62±172.294** | 661.66±48.604 |
| AUC0-t (ng.h/mL) | 891.97±73.132 | 1792.84±324.169** | 682.42±75.871 |
| AUC0-inf (ng.h/mL) | 964.65±75.843* | 1874.70±333.588** | 711.60±74.157 |
| AUMC0-inf (ng.h2/mL) | 515.96±352.64 | 1299.93±335.51** | 352.64±53.34 |
| MRT (h) | 0.61±0.050* | 0.76±0.194 | 0.53±0.107 |
| Cl (mg/kg)/(ng/mL)/h | 0.011±0.001 | 0.006±0.001 | 0.015±0.002 |
| Vss (mg/kg)/(ng/mL) | 0.006±0.001 | 0.005±0.002 | 0.008±0.002 |
Notes: *Significant difference compared at P-value ˂ 0.05 compared with curcumin solution. **Significant difference compared at P-value ˂ 0.05 compared with curcumin solution.
Abbreviations: Cmax, maximum concentrations; Tmax, time of maximum concentrations, AUC, area under the curve, t1/2, half-Life, AUMC, area under the first moment curve; Cl, clearance; MRT, mean residence time; Vss, steady-state volume of distribution; TPGS, D-α-tocopheryl polyethylene glycol 1,000 succinate; NS, nanosuspension.