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. 2019 Aug;25(8):1511–1521. doi: 10.3201/eid2508.181432

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Phenotypic memory biomarkers before and after primary and secondary 17DD vaccination for YF. Distinct T-cell memory subsets included naive T cells/(NCD4;NCD8)/CD27+CD45RO–; early effector memory T cells/(eEfCD4;eEfCD8)/CD27–CD45RO–; central memory T cells/(CMCD4;CMCD8)/CD27+CD45RO+ and effector memory T cells/(EMCD4;EMCD8)/CD27–CD45RO+. B-cell memory subsets included naive B cells/(NCD19)/CD27–IgD+; nonclassical memory B cells/(nCMCD19)/CD27+IgD+ and classical memory B cells/(CMCD19)/CD27+IgD–.We performed intra-arm analyses by paired t-test to compare memory-related phenotypic features observed in participants with previous vaccination with paired samples collected early after vaccination: NV(d0) versus PV(d30–45) and #PV(y≥10) versus RV(d30–45). Asterisks (*) indicate significant differences (p<0.05); vertical error bars indicate SEM. For intergroup analysis, we used adjusted analysis of variance to compare the memory-related phenotypic features observed among distinct time points; bars connecting subgroups indicate significant differences (p<0.05) between postvaccination subgroups. Participant subgroups indicate number of days or years since vaccination (in parentheses; d0 for those never vaccinated).