Table 2. Residue diversity between Zika virus isolate 31N from an Aedes aegypti larval pool and human- and mosquito-derived genomes, Jojutla, Morelos, Mexico*.

Position	Genome region	Human-derived sequences				Mosquito-derived sequence		p value
		SNVs, %	Origin of minority variant			SNVs, %	Origin of minority variant
1008	E	T→C, 3.65	Mexico, United States, Thailand			T→C, 17.64	31N, Mexico	0.000253
2071†	NS1	C→T, 0.26	French Polynesia			C→T, 2.94	31N	0.03
2871	NS2A	T→C, 4.43	Mexico, United States			T→C, 35.29	31N, Mexico, United States	<0.0001
3176‡	NS2A	CS				A→C, 2.94	31N	0.01022
3286‡	NS2A	CS				A→G, 2.94	31N	0.01022
3333†	NS2A	A→G, 0.52	Mexico			A→G, 2.94	31N	>0.05
3788	NS2A	C→T, 0.26	Brazil			C→T, 8.82	31N, Mexico	<0.0001
4500	NS2A	A→G, 3.65	Mexico, United States, Philippines, South Korea			A→G, 17.64	31N, Mexico	0.003847
4624	NS3	G→A, 3.39	United States, Mexico			G→A, 17.64	31N, Mexico	0.002194
4980	NS3	T→C, 6.00	Mexico, Puerto Rico, Colombia, United States			T→C, 17.64	31N, Mexico	0.01
5636‡	NS3	CS				C→T, 2.94	31N	0.01022
7200	NS5	T→A 0.26; T→C, 3.91§		Mexico, USA, Suriname		T→C, 17.64	31N, Mexico	0.006182
9139	NS5	C→T, 0.52	Mexico			C→T, 11.76	31N, Mexico	<0.0001

*CS, conserved site in human-derived sequences; SNV, single nucleotide variant.
†SNVs in human-derived sequences but not in other mosquito genomes. 
‡SNVs unique to the larva genome.
§Two SNVs located in the same genome position.