Table 5.
A Comparison Between Marfan Syndrome and Previously Healthy Women
| Variables | Marfan Syndrome, n = 61 | Previously Healthy Women, n = 31 | P Value |
|---|---|---|---|
| Case no., n (%) | 61 (50) | 31 (25.4) | 0.0001a |
| Age at the onset of AoD, y | 31.3 ± 4.4 | 31.6 ± 4.9 | 0.7465b |
| AoD onset time, gestation wk | 30.7 ± 8.6 | 34.4 ± 4.4 | 0.0263a |
| AoD during pregnancy, n (%) | |||
| First trimester | 3 (4.9) | 0 (0) | 0.0006a |
| Second trimester | 15 (24.6) | 0 (0) | |
| Third trimester | 43 (70.5) | 34 (100) | |
| Type of AoD, n (%) | |||
| Type A | 45 (73.8) | 25 (86.2) | 0.2782a |
| Type B | 16 (26.2) | 4 (13.8) | |
| Maximal dimension of the aorta, mm | 55.1 ± 15.4 | 60.3 ± 26.3 | 0.6047b |
| AoD involvement, n (%) | |||
| Coronary ostial involvement | 8 (13.1) | 3 (10.3) | 0.7446a |
| Aortic valve regurgitation | 22 (36.1) | 17 (58.6) | 0.0678a |
| Trivial | 1 (4.5) | 0 (0) | |
| Mild | 4 (18.2) | 5 (29.4) | 0.1447a |
| Moderate | 2 (9.1) | 5 (29.4) | |
| Severe | 15 (68.2) | 7 (41.2) | |
| Annuloaortic ectasia | 4 (6.6) | 2 (6.9) | 1.0000a |
| Mitral valve prolapse | 3 (4.9) | 0 (0) | 0.5482a |
| Cardiopulmonary bypass for AoD repair | |||
| Lowest core temperature, °C | 23.5 ± 5.9 | 23.0 ± 6.3 | 0.8425b |
| Cardiopulmonary bypass time, min | 232.4 ± 84.7 | 183.4 ± 75.9 | 0.1444b |
| Cross‐clamp time, min | 126.3 ± 42.4 | 94.3 ± 55.5 | 0.1646b |
| Circulatory arrest time, min | 45.8 ± 28.4 | 28.2 ± 8.0 | 0.1623b |
| Modality of delivery (excluding fetal demise) | |||
| Cesarean section, n (%) | 42 (89.4) | 22 (88) | |
| Postmortem cesarean section, n (%) | 0 (0) | 2 (8) | 0.1189a |
| Vaginal delivery (including instrumental), n (%) | 5 (10.6) | 1 (4) | |
| Maternal mortality, n (%) | 5 (8.2) | 7 (22.6) | 0.0972a |
| Fetus outcome | |||
| Body weight, g | 2538.4 ± 793.8 | 2517.6 ± 971.5 | 0.9413b |
| Apgar score at 1 min | 5.7 ± 3.0 | 3.3 ± 2.7 | 0.0269b |
| Apgar score at 5 min | 7.9 ± 1.9 | 6.0 ± 2.8 | 0.0250b |
| Intratracheal intubation and NICU stay, n (%) | 5 (8.2) | 9 (29.0) | 0.0134a |
| Feto‐neonatal death, n (%) | 8 (13.1) | 3 (9.7) | 0.7446a |
Abbreviations: AoD, aortic dissection; NICU, neonatal intensive care unit.
a
Fisher exact test.
b
Unpaired t test.
Data are presented as mean ± SD or n (%).