Table 1.
Clinical Characteristics and Electrocardiographic Findings According to BNP Tertiles (N = 102)
| All, N = 102 | BNP Tertiles, pg/mL | P | |||
|---|---|---|---|---|---|
| T1 (4.8–95.5), n = 34 | T2 (95.8–200), n = 34 | T3 (202–659), n = 34 | |||
| Age, y | 71 ± 12 | 68 ± 14 | 71 ± 12 | 75 ± 7.0 | 0.035 |
| Male, n (%) | 67 (65.7) | 24 (70.6) | 22 (64.7) | 21 (61.8) | 0.885 |
| Body mass index, kg/m2 | 24.0 ± 3.3 | 24.4 ± 3.4 | 24.4 ± 3.4 | 23.1 ± 3.1 | 0.558 |
| EHRA classification, n | |||||
| I / II | 80/22 | 30/4 | 28/6 | 22/12 | 0.049 |
| SBP, mm Hg | 133 ± 16 | 131 ± 12 | 132 ± 12 | 138 ± 23 | 0.711 |
| DBP, mm Hg | 75 ± 11 | 76 ± 12 | 76 ± 11 | 76 ± 10 | 0.917 |
| Diabetes, n (%) | 17 (16.7) | 5 (14.7) | 6 (17.6) | 6 (17.6) | 0.889 |
| Hypertension, n (%) | 55 (53.9) | 19 (55.9) | 17 (50.0) | 19 (55.9) | 0.946 |
| Dyslipidemia, n (%) | 33 (32.4) | 12 (35.3) | 10 (29.4) | 11 (32.4) | 0.577 |
| Creatinine, mg/dL | 0.86 ± 0.21 | 0.84 ± 0.18 | 0.82 ± 0.19 | 0.91 ± 0.25 | 0.316 |
| Medication, n (%) | |||||
| Digitalis | 46 (45.1) | 18 (52.9) | 15 (44.1) | 13 (38.2) | 0.313 |
| CCBs | 22 (21.6) | 7 (20.6) | 10 (29.4) | 5 (14.7) | 0.441 |
| β‐Blockers | 38 (37.3) | 10 (29.4) | 13 (38.2) | 15 (44.1) | 0.543 |
| ACEI/ARBs | 47 (46.1) | 14 (41.2) | 15 (44.1) | 18 (52.9) | 0.768 |
| Diuretics | 23 (22.5) | 7 (20.6) | 6 (17.6) | 10 (29.4) | 0.622 |
| Ambulatory electrocardiogram | |||||
| Max HR, bpm | 142.0 ± 28.1 | 143.4 ± 30.4 | 147.5 ± 25.9 | 135 ± 27.3 | 0.047 |
| Mean HR, bpm | 76.3 ± 12.7 | 75.4 ± 15.1 | 78.3 ± 11.9 | 75.3 ± 11.0 | 0.783 |
| Min HR, bpm | 41.8 ± 12.5 | 41.1 ± 12.7 | 41.6 ± 12.4 | 42.5 ± 12.9 | 0.587 |
| DIFF, bpm | 18.2 ± 9.6 | 21.1 ± 8.8 | 20.7 ± 9.7 | 12.8 ± 8.1 | 0.007 |
| SDRR | 222.8 ± 63.1 | 238.2 ± 72.8 | 223.0 ± 60.2 | 207.3 ± 52.4 | 0.576 |
| SDARR | 129.6 ± 57.5 | 145.6 ± 66.5 | 130.3 ± 52.2 | 112.4 ± 48.5 | 0.049 |
| RMSSD | 90.3 ± 17.2 | 92.6 ± 22.0 | 88.4 ± 17.7 | 90.4 ± 12.8 | 0.995 |
| pRR50 | 65.2 ± 13.2 | 67.0 ± 16.3 | 63.4 ± 11.6 | 65.1 ± 10.2 | 0.766 |
Abbreviations: ACEIs, angiotensin‐converting enzyme inhibitors; ARBs, angiotensin receptor blockers; BNP, B‐type natriuretic peptide; CCBs, calcium channel blockers; DBP, diastolic blood pressure; DIFF, difference of mean R‐R interval between night and day; EHRA, European Heart Rhythm Association; Max HR, maximum heart rate; Mean HR, mean heart rate; Min HR, minimum heart rate; pRR50, proportion of adjacent R‐R intervals varying by >50 ms; RMSSD, root‐mean‐square difference of successive R‐R intervals; SBP, systolic blood pressure; SDARR, standard deviation of the mean of all R‐R intervals for all 5‐minute segments; SDRR, standard deviation of all R‐R intervals; T, tertile.
Values are expressed as numbers with percentages in parentheses or as the mean ± standard deviation.