Table 1.
VLDL Characteristics in Adult and Pediatric Samples
| Adult Sample, n = 1 340 614 | Pediatric Sample, n = 10 294 | |
|---|---|---|
| Testing year | ||
| 2009 | 461 561 (34.4%) | 3347 (32.5%) |
| 2010 | 540 810 (40.4%) | 4294 (41.7%) |
| 2011 | 338 243 (25.2%) | 2653 (25.8%) |
| Age, y | 59 (49 to 70) [33 to 84] | 14 (11 to 16) [4 to 17] |
| Sex | ||
| Men | 692 752 (51.7%) | 5169 (50.2%) |
| Women | 640 102 (47.7%) | 5060 (49.2%) |
| Missing | 7760 (0.6%) | 65 (0.6%) |
| TC | 188 (159 to 220) [124 to 270] | 167 (145 to 191) [119 to 245] |
| HDL‐C | 52 (42 to 63) [32 to 86] | 50 (42 to 59) [33 to 74] |
| TG | 115 (82 to 166) [54 to 305] | 95 (67 to 140) [44 to 264] |
| TG ≥400 mg/dL | 30,174 (2.3%) | 144 (1.4%) |
| Friedewald estimated LDL‐C* | 106 (82 to 134) [54 to 177] | 93 (75 to 114) [53 to 160] |
| Directly measured LDL‐C | 108 (85 to 135) [58 to 178] | 94 (77 to 115) [55 to 162] |
| LDLr‐C | 88 (66 to 113) [41 to 151] | 78 (62 to 97) [42 to 138] |
| Non–HDL‐C | 133 (106 to 163) [76 to 212] | 115 (95 to 139) [71 to 191] |
| LDL pattern | ||
| A (large, buoyant) | 640 735 (47.8%) | 6581 (63.9%) |
| A/B (intermediate) | 265 055 (19.8%) | 1693 (16.5%) |
| B (small, dense) | 434 823 (32.4%) | 2020 (19.6%) |
| TC/HDL‐C | 3.5 (2.9 to 4.4) [2.2 to 6.1] | 3.3 (2.8 to 4.0) [2.2 to 5.7] |
| TG/HDL‐C | 2.2 (1.4 to 3.7) [0.7 to 8.1] | 1.9 (1.2 to 3.1) [0.7 to 7.0] |
| TG/TC | 0.6 (0.4 to 0.9) [0.3 to 1.6] | 0.6 (0.4 to 0.8) [0.3 to 1.5] |
| Lp(a)‐C | 6 (4 to 10) [2 to 18] | 6 (4 to 9) [3 to 17] |
| IDL‐C | 12 (8 to 16) [5 to 26] | 8 (6 to 12) [4 to 20] |
| VLDL‐C | 22 (17 to 29) [13 to 47] | 19 (16 to 25) [12 to 38] |
| LDL1‐C | 13 (8 to 18) [4 to 28] | 10 (6 to 15) [3 to 24] |
| LDL2‐C | 16 (8 to 28) [1 to 48] | 20 (12 to 29) [3 to 46] |
| LDL3‐C | 41 (29 to 56) [16 to 79] | 37 (27 to 49) [15 to 71] |
| LDL4‐C | 12 (7 to 19) [2 to 35] | 9 (5 to 13) [1 to 25] |
| HDL2‐C | 12 (9 to 17) [6 to 27] | 12 (9 to 16) [6 to 23] |
| HDL3‐C | 39 (33 to 47) [26 to 60] | 37 (32 to 43) [26 to 53] |
| VLDL1+2‐C | 9 (7 to 13) [5 to 24] | 8 (6 to 11) [5 to 20] |
| VLDL3‐C | 13 (10 to 16) [8 to 23] | 11 (9 to 13) [8 to 19] |
Abbreviations: HDL‐C, high‐density lipoprotein cholesterol; IDL‐C, intermediate‐density lipoprotein cholesterol; LDL pattern, low‐density lipoprotein modal density pattern; LDL‐Cd, directly measured low‐density lipoprotein cholesterol per traditional definition; LDLr‐C, directly measured low‐density lipoprotein real cholesterol; Lp(a)‐C, lipoprotein(a) cholesterol; non–HDL‐C, non–high‐density lipoprotein cholesterol; RLP, remnant lipoprotein cholesterol (IDL‐C + VLDL3‐C); TC, total cholesterol; TG, triglycerides; VLDL‐C, very low‐density lipoprotein cholesterol.
Lipid parameters, other than ratios, are reported in mg/dL. Median (25th to 75th percentile) and [5th to 95th percentile] presented for continuous variables. No. (%) presented for categorical variables.
*Reported in those with triglycerides <400 mg/dL; bottom limit set at 0.