Table 1.

Effects of Drug Treatment on Cardiovascular Risk Factors Compared With Placebo

	Phentermine/Topiramate29, 30, 31	Lorcaserin32, 33, 34	Buproprion/Naltrexone35, 36, 37, 38
Weight	↓↓	↓	↓
BP	↓	↓	↑
Heart rate	↑	↓	↑
HDL‐C	↑	↑	↑
LDL‐C	↓	↓	↓
Triglycerides	↓	↓	↓
Fasting glucose	↓	↓	↓
HbA1c in T2DM	↓	↓	↓
hs‐CRP	↓	↓	↓

Abbreviations: BP, blood pressure; hs‐CRP, C‐reactive protein; HbA_1c, glycated hemoglobin; HDL‐C, high‐density lipoprotein cholesterol; LDL‐C, low‐density lipoprotein cholesterol; T2DM, type 2 diabetes mellitus.

Arrows indicate that drug treatment compared with placebo caused a statistically significant change in outcome variable in ≥1 randomized, controlled clinical trial.