Table 3.
Unadjusted and Multivariate Adjusted HRs for 10‐Month Clinical Endpoints
| HR (95% CI) | ||
|---|---|---|
| Unadjusted | Multivariate Adjusted | |
| All‐cause death (n = 25) | ||
| Quartiles | ||
| 1 | 1.00 | 1.00 |
| 2 | 2.22 (0.55–8.86) | 1.51 (0.33–6.83) |
| 3 | 2.16 (0.52–9.06) | 1.86 (0.44–7.87) |
| 4 | 3.94 (1.10–14.13)a | 3.97 (1.09–14.41)a |
| MI (n = 31) | ||
| Quartiles | ||
| 1 | 1.00 | 1.00 |
| 2 | 0.75 (0.29–1.97) | 0.67 (0.24–1.85) |
| 3 | 0.86 (0.33–2.27) | 0.74 (0.27–2.04) |
| 4 | 0.75 (0.29–1.98) | 0.71 (0.27–1.88) |
| Primary composite (n = 117) | ||
| Quartiles | ||
| 1 | 1.00 | 1.00 |
| 2 | 1.20 (0.73–1.98) | 1.10 (0.66–1.85) |
| 3 | 1.12 (0.68–1.90) | 0.99 (0.57–1.70) |
| 4 | 1.11 (0.66–1.84) | 0.98 (0.57–1.66) |
| CHF (n = 27) | ||
| Quartiles | ||
| 1 | 1.00 | 1.00 |
| 2 | 1.29 (0.43–3.85) | 1.34 (0.44–4.08) |
| 3 | 1.27 (0.41–3.95) | 0.76 (0.22–2.58) |
| 4 | 1.58 (0.56–4.44) | 1.73 (0.60–4.97) |
Abbreviations: BNP, B‐type natriuretic peptide; CHF, congestive heart failure; CI, confidence interval; CrCl, creatinine clearance; HR, hazard ratio; MI, myocardial infarction. Multivariate adjustment of risk included the following variables: age, diabetes, prior MI, prior CHF, ST deviation (>1 mm), CrCl, BNP (>80 pg/mL), current smoking, and Killip class (I vs II–IV).
The interval increased HR for the fourth quartile of catalytic iron was statistically significant for both the unadjusted (P = 0.035) and multivariate adjusted models (P = 0.036).