Table 1.

Demographics and medical history of Discovery and ADNI cohorts.

Factor	Discovery cohort (N = 48)		ADNI cohort (N = 43)		P‐value
	n	Statistics	n	Statistics
Age at enrollment	48	68.1 ± 7.3	43	76.1 ± 6.5	<0.001a
Gender	48		43		0.11c
Male		28 (58.3)		32 (74.4)
Female		20 (41.7)		11 (25.6)
Years of education	48	16.0 [12.5, 18.0]	43	16.0 [15.0, 18.0]	0.12b
APOEε4 positive	48	37 (77.1)	43	21 (48.8)	0.005c
MMSE	48	24.8 ± 3.1	43	26.6 ± 1.6	<0.001a
CDR‐SB	48	2.2 ± 1.3	43	1.5 ± 0.79	0.003a
DRS	47	125.6 ± 10.3		NA
CSF Aβ42, pg/mL	48	305.9 [216.1, 367.1]	43	144.0 [135.0, 167.0]	<0.001b
CSF t‐tau, pg/mL	48	454.3 [335.1, 771.]	43	91.0 [64.0, 132.0]	<0.001b
CSF p‐tau, pg/mL	48	79.6 [59.3, 104.6]	43	33.0 [21.0, 42.0]	<0.001b

Statistics presented as Mean ± SD, Median [P25, P75] or N (column %).

P‐values: a = ANOVA, b = Kruskal–Wallis test, c = Pearson's chi‐square test.

MMSE, Mini‐mental state exam; CDR‐SB, Clinical dementia rating scale‐sum of boxes.

DRS, Dementia rating scale. P values in bold meet statistical significance <0.05.