Table 4.
Significant associations between Plasma inflammatory analytes and CSF neurodegenerative markers (adjusted for age, sex, APOEε4, and MMSE) in discovery cohort.
| Factor 1 | Factor 2 | N | Pearson r (95% CI) | Unadjusted P‐value | False discovery rate (FDR) P‐value |
|---|---|---|---|---|---|
| ABeta42 | CCL4 | 46 | 0.39 (0.09, 0.61) | 0.011 | 0.35 |
| AAT | 46 | 0.31 (0.01, 0.56) | 0.042 | 0.41 | |
| Total Tau | A2M | 46 | 0.38 (0.08, 0.61) | 0.013 | 0.20 |
| ICAM1 | 45 | −0.40 (−0.63, −0.10) | 0.009 | 0.20 | |
| PhosphoTau | A2M | 46 | 0.49 (0.22, 0.69) | <0.001 | 0.023 |
| ICAM1 | 45 | −0.36 (−0.60, −0.05) | 0.020 | 0.31 | |
| VEGF | 45 | −0.43 (−0.65, −0.13) | 0.005 | 0.10 | |
| NSE | MMP9 | 45 | 0.57 (0.31, 0.74) | <0.001 | 0.002 |
| Haptoglobin | 46 | −0.39 (−0.62, −0.09) | 0.010 | 0.16 |
FDR P values in bold meet statistical significance < 0.05.