Table 1.

Cell numbers and pairs of CD8⁺ cells in MS patients and controls

Patient	Diagnosis	Age	Average number of cells/mm2						Pairs		Perforin expression
			CD8		CD163		CD11b
			Parench.	Periv.	Parench.	Periv.	Parench.	Periv.	CD8/CD11b/CD163	CD163/CD8/perforin
A10aa	AMS	49	95	51	379	120	310	75	Yes	Yes	+/++
A12ba	AMS	49	87	8	187	15	257.5	31	Yes	Yes	+/++
A11aa	AMS	49	56	14	0	4	169	9.5	No	No	+
A11ba	AMS	49	30.5	2.5	0	2	95	6	No	No	+
MS11b	AMS	78	91	12	400	55	24	2	Yes	Yes	+/++
MS10b	AMS	69	2	10	410	60	51	14.5	Yes	Yes	+
MS3b	AMS	45	2.5	60	71	60	110	34	Yes	No	−/+
MS4b	AMS	45	1	6	0	10	31	45	No	No	ND
MS2b	AMS	35	1	14	51	10	7	61	Yes	No	−
MS25b	SPMS	48	3	20	360	40	14	16	Yes	Yes	+
MS22b	SPMS	41	1	35	112	90	35.5	54.5	Yes	No	−/+
MS1854c	PPMS	42	2	16	5	8	4	2	No	No	+
NMO 499d	NMO	20	6.5	20	276	35	308	48	Yes	No	+
Y304/12/52	Rasmussen	9	25	10	0	40	15	5	No	No	−/+

Patients, diagnoses, and ages are listed in columns 1–3. Four different tissue blocks (10a, 12b, 11a, and 11b) from a biopsy sample from patient A were used. Columns 4–9 list median cell numbers/mm² for CD8⁺ (columns 4 and 5) CD163⁺ cells (columns 6 and 7) and CD11b+ cells (columns 8 and 9) detected in the parenchyma (Parench.) (columns 4, 6, and 8) and perivascular (Periv.) space (columns 5, 7, and 9). Cell numbers/mm² were determined in areas with high inflammatory activity. Column 10 lists whether or not CD8⁺ cells could be detected in direct contact with CD11b⁺CD163⁺ cells. In column 11 we list whether or not CD8⁺ cells in direct contact with CD163⁺ cells expressed perforin. In column 12 we give a semi‐quantitative estimation of the perforin expression level in CD8⁺ cells irrespective of whether they contacted CD163⁺ cells or not: ND = not done; “−” = not present; “−/+” = weak expression or <10% CD8⁺ cells; “+” = moderate expression or in 10–40% of CD8⁺ cells; “++” = strong expression or in more than 40% CD8⁺ cells; AMS, acute multiple sclerosis.

^aPatient described in Ref. 10.

^bPatients described in Ref. 9.

^cPatient MS1854 represents "MS4" in Ref. 12.

^dPatient described in Ref. 39.