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. 2019 Jul 1;18(15):1798–1811. doi: 10.1080/15384101.2019.1634956

Figure 3.

Figure 3.

Validation of a combinatorial effect of the 111 miRNA mimics in combination with miR-34a in a panel of NSCLC cell lines. (a) Validation of sulforhodamine B (SRB) method for secondary verification of screen hits. Absorbance of SRB as a linear response to H441-pmiR cell number. Error bars: mean ± s.d., n = 6. (b) Response of H441-pmiR to miR-34a measured by SRB. Error bars: mean ± s.d., n = 6. (c) miRNA combinations evaluated in a panel of six NSCLC cell lines. miRNAs included in this comparison had a CI lower than 1 (potential synergism), p < 0.05 and cell proliferation of the single miRNA was <1.