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. 2019 Jul 1;18(15):1798–1811. doi: 10.1080/15384101.2019.1634956

Figure 4.

Figure 4.

Evaluation of synergism of positive hits. The possibility of synergism with miR-34a was evaluated for (a) miR-6715b, (b) miR-4664-3p, (c) miR-3157-3p, (d) miR-5100 and (e) let-7a-2-3p. (For A-E. red lines: miR-34a alone, blue lines: putative synergistic miRNA alone, green lines: combination) miRNA combinations have a stronger effect than each miRNA on its own. (f) Evaluation of synergism using the (CI)-isobologram equation. The equation helps to gain a better understanding of drug interactions, where CI < 1 indicate synergism. Statistical analysis performed with one-way ANOVA with post hoc Bonferroni correction (***, P < 0.001; ****, P < 0.0001).