Table 1.
Genes predicted to be the targets of at least three miR-34a synergistic miRNAs.
| Predicted targets of four/five miRNAs | Functional roles in cancer |
|---|---|
| APBB2 | Processing of APBB2 promotes proliferation of human embryonic stem cells (hESC)49 |
| CTDSPL2 |
Regulate cell cycle progression in multiple cancers50,51 |
| Predicted targets of three/five miRNAs |
Functional roles in cancer |
| CNOT6L | Promote cell proliferation and survival through prevention of cell senescence and death in breast cancer cells52 |
| PCSK1 | Elevated in expression in human lung cancer53 |
| RAD21 | Important for cell growth of multiple cancers and recognized as a predictive biomarker for poor prognosis54–56 |
| ROBO2 | Functions as a tumor suppressor in prostate cancer57 |
| SP1 | Recognized as an oncogene for many cancers including lung cancer58,59 |
| PRLR | Positively contributes to the initiation and progression of prostate cancer60 |
| POU2F2 | Promotes human gastric cancer and also been shown to be amplified in B cell lymphoma61,62 |
| MTSS1 | [Acts as a tumor and metastasis suppressor63,64 |
| ACVR2B | Not reported |
| REEP1 | Not reported |
| INO80D | Not reported |
| ZBTB44 | Not reported |
| ZFAND5 | Not reported |