Table 3.

Characteristics of Patients Having Reactions During Desensitization

Characteristic	No. of Patients, N = 16 (% or SD)
Sex
M	10 (62.5)
F	6 (37.5)
Age	62.69 ± 12.213
Race
White	13 (81.3)
Black	3 (18.8)
Asthma	4 (25)
Polyps	1 (6.3)
Allergic rhinitis	2 (12.5)
Chronic urticaria	1 (6.3)
Chronic angioedema	1 (6.3)
Reported allergy to other medications	13 (81.3)
Initial reaction to ASA involving:
Rash or hives	11 (68.8)
Angioedema	12 (75)
SOB or wheeze	2 (12.5)
Time since last reaction, y
<1	5 (31.3)
2–5	2 (12.5)
6–10	3 (18.8)
11–20	1 (6.3)
>20	2 (12.5)
DS performed inpatient	11 (68.8)
DS performed outpatienta	5 (31.2)
On antihistamines, LTRAs, or systemic steroids at time of procedure	8 (50)
On β‐blocker at time of procedure	7 (43.8)
Reaction time after previous dose, h	9.8 ± 1.2
Reaction before next dose (<20 min)	5 (31.25)
Reaction after protocol complete	7 (43.75)
Reaction at dose <105 mg	7 (43.75)
Protocol require adjustment	6 (37.5)
Discharged on ASA	11 (68.8)
Still on ASA	6 (37.5)
Stop ASA later because of reaction	1 (6.3)

Abbreviations: ASA, aspirin; DS, desensitization; F, female; LTRAs, leukotriene antagonists; M, male; SD, standard deviation; SOB, shortness of breath.

^aOne of these patients had initial DS as an outpatient and had a reaction; subsequent protocol as an inpatient was completed with no reaction.