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. 2019 Jun 26;18(15):1759–1769. doi: 10.1080/15384101.2019.1632638

Figure 2.

Figure 2.

The effect of CF on DANCR expression through miR-34a-5p. (a) Target gene prediction database (LncBase Predicted v.2) predicted a combination of miR-34a-5p and DANCR. (b) The luciferase activity of DANCR-WT or DANCR-Mut in HEK-293 cells co-transfected with miR-34a-5p inhibitor or miR-34a-5p mimic was measured using dual luciferase reporter assay. (c) Jagged1 expression in hPDL cells transfected with miR-34a-5p inhibitor or miR-34a-5p mimic. (d) The binding between miR-34a-5p and DANCR was measured using RIP assay. *P < 0.05 vs. NC; #P < 0.05 vs. pre-NC. (e) hPDL cells were divided into control, CF, CF+pre-NC, and CF+miR-34a-5p mimic group. MiR-34a-5p expression was measured by qRT-PCR. (f) DANCR expression in hPDL cells. *P < 0.05 vs. control; #P < 0.05 vs. CF+pre-NC.