Figure 6.

Knockdown of DANCR reduced root resorption in rat OTM model. Rats were divided into si-control and si-DANCR group. Each group had six rats. si-DANCR or si-control (1 nmol/time, 50 μl) was local injected into the buccal and lingual submucous between the first and second molars for three consecutive days. After seven days, PDL tissues of each rat were obtained for for TRAP staining, qRT-PCR and western blot. (a) The number of TRAP-positive osteoclasts. (b) The expressions of DANCR, Jagged1 and RANKL in PDL tissues. *P < 0.05 vs. si-control.