Figure 2.

Lysosomal Membrane Permeability (LMP) and Lysosomal Leakage (LL) determine cell survival based on the cellular expression levels of Heat Shock Proteins (HSP), Cystatins, anti-oxidants, Sphingomyelin, Cholesterol, LAMP1/2 and Bcl-2. Cell death can also be induced by the lysosome, based upon cellular levels of Reactive Oxidative Species (ROS), Cathepsin, Lysosomorphic Agents, Lysosomal Leakage, Microtubule Disrupting drugs, Viral Proteins, Toxins, Lipids and Metabolites, protein p53 and protein BID (see text for more details).