Table 3.

Multivariate Analysis of Change in Exercise Capacity From Baseline

Model	Base Model, n = 1290a			Including Diastolic Function, n = 723a
	PE	SE	P Value	PE	SE	P Value
DM	−0.86	0.150	<0.001	−0.97	0.209	<0.001
Age per 10 years	−0.55	0.051	<0.001	−0.63	0.074	<0.001
Female sex	−1.29	0.148	<0.001	−1.43	0.200	<0.001
BMI per kg/m2	−0.05	0.011	<0.001	−0.06	0.015	<0.001
Lung disease	−0.44	0.123	<0.001	−0.33	0.171	0.05
LVEF <35% vs ≥50%	−0.63	0.188	<0.001	−0.55	0.267	0.04
LVEF 35%–50% vs ≥50%	−0.03	0.132	0.82	−0.06	0.181	0.75
On statin therapy	0.23	0.169	0.18	0.25	0.220	0.25
3‐Way interaction term for DM, female sex, BMI	0.02	0.008	0.006	0.03	0.011	0.02
Abnormal diastolic function				−0.50	0.171	0.004

Abbreviations: BMI, body mass index; DM, diabetes mellitus; LVEF, left ventricular ejection fraction; METs, metabolic equivalents; PE, parameter estimate; SE, standard error of parameter estimate.

^aOnly patients with nonmissing values for covariates included in the model. Parameter estimates indicate the multivariable adjusted absolute mean change in METs from baseline to peak associated with each covariate.