Table 1.
Baseline subjects’ demographic and lipoprotein particle data.
| Lean-IS | Obese-IR | P | Adjusted P∗ | |
|---|---|---|---|---|
| Age (years) | 23.2 ± 0.2 | 28.6 ± 1.4 | 0.002 | |
| BMI (kg/m2) | 22.0 ± 0.2 | 30.1 ± 0.7 | <0.001 | <0.001 |
| Waist Circumference (cm) | 79.9 ± 0.5 | 100.8 ± 1.0 | <0.001 | <0.001 |
| HOMA-IR | 0.83 ± 0.10 | 4.34 ± 0.41 | <0.001 | <0.001 |
| VLDL and CM Particle Concentration (nmol/L) | ||||
| Total | 58.50 ± 5.08 | 44.60 ± 7.19 | 0.136 | 0.112 |
| Large | 1.78 ± 0.37 | 6.19 ± 0.90 | 0.001 | 0.003 |
| Medium | 1.48 ± 0.83 | 3.83 ± 1.20 | 0.130 | 0.761 |
| Small | 55.23 ± 5.35 | 34.58 ± 7.79 | 0.046 | 0.062 |
| LDL Particle Concentration (nmol/L) | ||||
| Total | 702.63 ± 60.67 | 1161.15 ± 92.57 | 0.001 | 0.001 |
| Large | 218.33 ± 52.79 | 161.70 ± 59.97 | 0.489 | 0.588 |
| Small | 265.41 ± 49.95 | 854.96 ± 105.88 | 0.001 | 0.001 |
| IDL Particle Concentration (nmol/L) | ||||
| IDL | 218.85 ± 15.13 | 144.44 ± 19.01 | 0.033 | 0.025 |
| HDL Particle Concentration (μmol/L) | ||||
| Total | 30.04 ± 1.23 | 30.17 ± 1.58 | 0.949 | 0.055 |
| Large | 10.25 ± 0.73 | 5.64 ± 0.66 | 0.001 | 0.001 |
| Medium | 14.42 ± 1.02 | 12.13 ± 1.71 | 0.270 | 0.025 |
| Small | 5.38 ± 0.48 | 12.39 ± 2.15 | 0.006 | 0.007 |
| Mean Particle Size (nm) | ||||
| VLDL | 40.58 ± 1.65 | 56.09 ± 3.88 | 0.002 | 0.015 |
| LDL | 20.60 ± 0.16 | 19.99 ± 0.11 | 0.006 | 0.045 |
| HDL | 10.06 ± 0.08 | 9.21 ± 0.08 | 0.001 | 0.001 |
| NMR Calculated Concentration (mg/dl) | ||||
| Total Triglyceride | 61.18 ± 5.25 | 125.70 ± 17.39 | 0.003 | 0.088 |
| Total VLDL and CM Triglyceride | 61.18 ± 3.28 | 97.93 ± 10.53 | 0.004 | 0.192 |
| Total HDL Cholesterol | 58.52 ± 2.37 | 39.82 ± 3.18 | 0.001 | 0.001 |
Data are presented as the mean ± SEM; n = 9 for each group. P < 0.05 is considered significant. ∗P value adjusted for age.