Table 3.

Proportions of women with breast edema after various types of treatments as part of breast-conserving therapy (n = 836)

Variables	Breast edema
	Baseline		3 months		6 months		12 months		18 months
	%	P *	%	P *	%	P *	%	P *	%	P *
Neoadjuvant chemotherapy with immunotherapy
Yes (n = 88)	12.5	—	5.1	—	12.0	—	11.4	—	4.4	—
No (n = 699)	10.9	.65	7.2	.48	12.3	.94	8.0	.33	5.7	.72
Oncoplastic surgery
Yes (n = 92)	20.0	—	10.2	—	12.2	—	4.1	—	5.3	—
No (n = 396)	10.2	.04	7.1	.44	12.2	.99	6.6	.50	5.5	.99
Sentinel node biopsy
Yes (n = 705)	10.1		5.7	—	11.8	—	8.2	—	5.5	—
No (n = 131)	11.1	.40	6.3	.45	15.5	.26	8.0	.95	5.6	.95
Axillary lymph node dissection
Yes (n = 120)	25.8	—	14.4	—	22.0	—	14.7	—	10.7	—
No (n = 716)	9.6	<.01	5.8	<.01	10.8	<.01	7.0	<.01	4.6	.04
Radiotherapy
Local (n = 656)	N/A	—	5.8	—	11.0	—	7.1	—	5.3	—
Locoregional† (n = 180)	N/A	—	10.5	.04	17.1	.04	12.8	.03	6.8	.65
Local radiotherapy boost
Yes (n = 286)	N/A	—	4.6	—	12.0	—	7.7	—	8.1	—
No (n = 459)	N/A	—	6.8	.31	10.2	.51	6.7	.74	2.8	.01
Adjuvant chemotherapy
Yes (n = 232)	N/A	—	5.7	—	22.4	—	14.8	—	11.2	—
No (n = 604)	N/A	—	7.6	.35	8.4	<.01	5.4	<.01	2.9	<.01
Adjuvant endocrine therapy
Yes (n = 656)	N/A	—	7.6	—	14.8	—	9.7	—	6.1	—
No (n = 180)	N/A	—	6.7	.58	10.4	.08	7.0	.19	5.0	.59
Continuous variables	Median (IQR)	P ‡
Age, y
Breast edema	58 (16)
No breast edema	58 (16)	.62
Tumor size, mm
Breast edema	17 (14)
No breast edema	13 (10)	<.001

^* P value based on two-sided χ² test. IQR = interquartile range; N/A = at-baseline radiotherapy and adjuvant chemotherapy have not yet been initiated.

^†Includes radiotherapy on axillary and/or periclavicular lymph nodes.

^‡ P value based on Mann-Whitney U test.