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. 2018 Nov 16;2(3):pky047. doi: 10.1093/jncics/pky047

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© The Author(s) 2018. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Relationship of Myc activity signature to molecular alterations of Myc family genes and the prognostic significance in endometrioid epithelial ovarian cancer (EOC). A) Myc activity levels were compared between tumors without Myc alteration (NO) and those with either gain or amplification (GAIN/AMP) in endometrioid EOC. Welch’s t test was used to determine different levels of Myc activity. B–D) Expression levels of MYC (B), MYCN (C), or MYCL1 (D) genes were also measured using qPCR and correlated to signature score in EOC. E,F) Kaplan–Meier analysis of signature scores in 61 endometrioid EOC was conducted for PFS (E) and OS (F). Signature scores were dichotomized at upper quartile in the overall cohorts of each tumor. P values were obtained from the log-rank test in each case.