Figure 1.

Prevalence of exclusions for 19 common chronic conditions explicitly or implicitly excluded from National Cancer Institute-funded breast cancer trials (N = 58 trials)*. COPD = chronic obstructive pulmonary disease; TIA = transient ischemic attack. *Conditions were adapted from the list of the most impactful chronic conditions compiled by a multiple chronic conditions working group at the Office of the Assistant Secretary of Health (12). Conditions were coded as explicitly excluded if exclusion criteria directly named a condition and as being implicitly excluded if the exclusion criteria used terms that encompassed the condition without directly naming it.