Table 3.
The association between number of risky lifestyle behaviors and breast cancer overall and subtypes
| Breast cancer overall |
Luminal A–like |
Luminal B–like HER2 negative |
Luminal B–like HER2 positive |
HER2-positive |
Triple-negative |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ER+PR+HER2- |
ER+PR-HER2- |
ER+PR+/PR-HER2+ |
ER-PR-HER2+ |
ER-PR-HER2- |
||||||||
| No. ca/co | OR* (95% CI) | No. ca/co | OR (95% CI) | No. ca/co | OR (95% CI) | No. ca/co | OR (95% CI) | No. ca/co | OR (95% CI) | No. ca/co | OR (95% CI) | |
| No. of risky lifestyle behaviors | ||||||||||||
| 0 | 99/865 | 1 (ref) | 56/496 | 1 (ref) | 19/117 | 1 (ref) | 6/58 | 1 (ref) | 4/29 | 1 (ref) | 14/67 | 1 (ref) |
| 1 | 530/3401 | 1.34 (1.06 to 1.68) | 307/1922 | 1.38 (1.02 to 1.88) | 96/453 | 1.32 (0.77 to 2.26) | 35/267 | 1.21 (0.48 to 3.04) | 42/132 | 2.52 (0.81 to 7.78) | 50/238 | 0.95 (0.49 to 1.84) |
| 2 | 1076/6928 | 1.36 (1.09 to 1.70) | 675/3842 | 1.57 (1.17 to 2.10) | 184/994 | 1.17 (0.70 to 1.96) | 90/518 | 1.58 (0.65 to 3.81) | 47/290 | 1.23 (0.41 to 3.70) | 80/517 | 0.72 (0.38 to 1.37) |
| 3 | 1365/6990 | 1.67 (1.34 to 2.08) | 847/3933 | 1.89 (1.41 to 2.53) | 217/1030 | 1.32 (0.79 to 2.20) | 135/506 | 2.29 (0.96 to 5.48) | 56/307 | 1.35 (0.45 to 4.06) | 110/483 | 1.05 (0.56 to 1.96) |
| 4 | 824/3847 | 1.82 (1.45 to 2.28) | 559/2144 | 2.29 (1.70 to 3.09) | 116/570 | 1.24 (0.73 to 2.12) | 65/260 | 2.11 (0.86 to 5.18) | 28/154 | 1.26 (0.40 to 3.94) | 56/317 | 0.79 (0.41 to 1.52) |
| 5 | 187/877 | 1.85 (1.42 to 2.42) | 120/483 | 2.20 (1.55 to 3.12) | 25/130 | 1.18 (0.61 to 2.27) | 15/77 | 1.66 (0.61 to 4.54) | 6/23 | 1.82 (0.45 to 7.39) | 21/63 | 1.53 (0.70 to 3.36) |
| OR per behavior | 1.13 (1.10 to 1.17) | 1.19 (1.14 to 1.24) | 1.07 (0.93 to 1.10) | 1.16 (1.03 to 1.30) | 0.88 (0.75 to 1.04) | 1.08 (0.96 to 1.22) | ||||||
| Ptrend | <.0001 | <.0001 | .75 | .004 | .19 | .42 | ||||||
*
OR mutually adjusted for education (no education/primary school, high school, Bachelor’s and Master’s +), age at menarche (9–12, 13, 14, 15–18 years), number of pregnancies (never, 1, 2, 3, ≥4), and menopausal status (pre-, peri-, postmenopausal). BMI = body mass index; ca/co = case/control subjects; CI = confidence interval; ER = estrogen receptor; HER2 = human epidermal growth factor receptor 2; OR = odds ratio; PR = progesterone receptor.