Table 2.
Association between prolactin levels (ng/mL) and mammographic density, described using cBIRADS, stratified by menopausal and case-control status
| cBIRADS |
% increase per cBIRADS* | |||||
|---|---|---|---|---|---|---|
| Category | 1 | 2 | 3 | 4 | Ptrend* | |
| Premenopausal women | ||||||
| No. of cases/controls | 5/21 | 42/107 | 113/202 | 67/68 | ||
| Prolactin, ng/mL, geometric mean†, all women, multivariable model | 13.3 | 15.3 | 15.9 | 16.8 | 8.2 | .12 |
| Prolactin, ng/mL, geometric mean†, controls, multivariable model | 12.7 | 14.9 | 15.5 | 15.7 | 7.5 | .28 |
| Prolactin, ng/mL, geometric mean†, cases, multivariable model | 19.0 | 17.1 | 16.5 | 17.7 | −2.1 | .82 |
| Postmenopausal women | ||||||
| No. of cases/controls | 62/189 | 224/475 | 172/273 | 14/25 | ||
| Prolactin, ng/mL, geometric mean‡, all women, multivariable model | 10.8 | 11.1 | 11.9 | 11.9 | 3.3 | .03 |
| Prolactin, ng/mL, geometric mean‡, controls, multivariable model | 11.1 | 11.0 | 11.8 | 11.4 | 1.0 | .31 |
| Prolactin, ng/mL, geometric mean‡, cases, multivariable model | 9.7 | 11.1 | 11.9 | 13.1 | 10.6 | .03 |
Average percentage change in prolactin level per category increase in mammographic density by computer-generated breast imaging reporting and data system score (cBIRADS). P value (two-sided) based on F-test with natural log-transformed prolactin (ng/mL), continuous, and cBIRADS as dependent variable. cBIRADS = computer-generated breast imaging reporting and data system score.
Adjusted for age and body mass index at blood draw, benign breast disorder (no, yes), breast cancer in family (no, yes), smoking status (never, previous, or current smoker), age at menarche, and number of births (0, 1, 2, or ≥3).
Adjusted for age and body mass index at blood draw, benign breast disorder (no, yes), breast cancer in family (no, yes), smoking status (never, previous, or current smoker), age at menarche, number of births (0, 1, 2, or ≥3), and ever use of hormone replacement therapy.