. 2018 Dec 4;2(4):pky055. doi: 10.1093/jncics/pky055

Table 3.

Multivariable adjusted odds ratios for risk of breast cancer as a function of prolactin levels (ng/mL), given in quintals with and without addition of mammographic density, stratified by menopausal status

		Plasma prolactin level (ng/mL), quintiles^*
		1st	2nd	3rd	4th	5th
Category	No. of cases/controls	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)
Premenopausal women
Multivariable^†	211/381	1.0	1.24 (0.70 to 2.2)	1.08 (0.60 to 1.94)	1.21 (0.68 to 2.15)	1.88 (1.08 to 3.26)
Multivariable^† + Density^‡	207/380	1.0	1.26 (0.71 to 2.25)	1.12 (0.62 to 2.03)	1.13 (0.63 to 2.03)	1.77 (1.00 to 3.12)
Postmenopausal women
Multivariable^§	436/904	1.0	1.32 (0.91 to 1.91)	1.30 (0.90 to 1.87)	1.04 (0.71, 1.53)	1.07 (0.73 to 1.57)
Multivariable^§ + Density^‡	436/896	1.0	1.34 (0.93 to 1.95)	1.27 (0.88 to 1.85)	1.07 (0.72 to 1.57)	1.03 (0.70 to 1.51)

Premenopausal: Q1: <7.01 ng/mL, Q2: 7.01–9.43, Q3: 9.44–12.42, Q4: 12.4–17.22, Q5: >17.22. Postmenopausal: Q1: <9.27 ng/mL, Q2: 9.28–12.89, Q3: 12.90–17.52, Q4: 17.53–24.33, Q5: >24.33. BMI = body-mass index; CI = confidence interval; OR = odds ratio.

^†

Adjusted for age and body mass index at blood draw, benign breast disorder (no, yes), breast cancer in family (no, yes), smoking status (never, previous, or current smoker), age at menarche, and number of births (0, 1, 2, or ≥3).

^‡

Percentage mammographic breast density by STRATUS.

^§