Table 4.
Risk of breast cancer as a function of mammographic density, measured as cBIRADS, with and without addition of prolactin, stratified by menopausal status
| cBIRADS* |
|||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | ||
| Category | No. of cases/controls | OR (ref.) | OR (95% CI) | OR (95% CI) | OR (95% CI) |
| Premenopausal women | |||||
| Multivariable† | 205/375 | 1.0 | 2.27 (0.69 to 7.45) | 3.49 (1.05 to 11. 55) | 6.97 (1.97 to 24.66) |
| Multivariable† + Prolactin‡ | 204/373 | 1.0 | 2.13 (0.65 to 7.00) | 3.26 (0.98 to 10.83) | 6.37 (1.79 to 22.63) |
| Postmenopausal women | |||||
| Multivariable§ | 435/898 | 1.0 | 1.79 (1.24 to 2.58) | 2.79 (1.83 to 4.25) | 2.54 (1.13 to 5.73) |
| Multivariable§ + Prolactin‡ | 433/890 | 1.0 | 1.79 (1.24 to 2.58) | 2.75 (1.80 to 4.19) | 2.51 (1.12 to 5.66) |
computer-generated breast imaging reporting and data system score (cBIRADS) based on scale cut-points of mammographic density (<2%, 2–16%, 17–48%, ≥49%). BMI = body-mass index; CI = confidence interval; OR = odds ratio.
Adjusted for age and BMI at blood draw, benign breast disorder (no, yes), breast cancer in family (no, yes), smoking status (never, previous, or current smoker), age at menarche, and number of births (0, 1, 2, or ≥3).
Prolactin concentration, continuous (ng/mL).
Adjusted for age and BMI at blood draw, benign breast disorder (no, yes), breast cancer in family (no, yes), smoking status (never, previous, or current smoker), age at menarche, number of births (0, 1, 2, or ≥3), and ever use of hormone replacement therapy.