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PCA results obtained for ChVLig (black) and its 189insG mutant (green) in complex with ds2′OMe-RNA (plots A and B) and dsHNA (plots C and D). For comparison, results on the wild-type ligase complexed with dsDNA is superimposed in orange on all plots. The motion of the mutant-dsXNA complexes (plots B and D, green) clearly converges towards the native state, in comparison to ChVLig–dsXNA complexes (plots A and C, black).
