Figure 2.

Distribution of the Cirrus measure created on the combined studies, adjusted for age and BMI, for cases (gray line) and controls (dark line). Risk increases with increasing Cirrus. The difference in the mean between cases and controls is equal to the log of the OR per standard deviation, which in turn is linearly related to the area under the receiver operator curve (AUC) in the range of 0.5 to 0.7; see theory and references in the Supplementary Methods (available online). See also Figure 3, which shows the corresponding receiver operator curve.