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. 2019 Apr 9;3(1):pkz008. doi: 10.1093/jncics/pkz008

Figure 3.

Figure 3.

Estimated risk to male and female fertility from select pediatric chemotherapy regimens using calculated cyclophosphamide equivalent dose (CED) and cisplatin exposures. *CED dose (mg/m2) = 1.0 (cyclophosphamide dose [mg/m2]) + 0.244 (ifosfamide dose [mg/m2]) + 0.857 (procarbazine dose [mg/m2]) + 14.286 (chlorambucil dose [mg/m2]) + 15.0 (carmustine dose [mg/m2]) + 16.0 (lomustine dose [mg/m2]) + 40 (melphalan dose [mg/m2]) + 50 (thiotepa dose [mg/m2]) + 100 (nitrogen mustard dose [mg/m2]) + 8.823 (busulfan dose [mg/m2]). HR = hazard ratio.