Table 1.

WISDOM risk stratification and screening recommendations (13)

Risk	Highest risk	Elevated risk	Average risk	Lowest risk
Criteria/ threshold	BRCA1/2, TP53, PTEN, STK11, CDH1, ATM, PALB2, or CHEK2 mutation carrier	Women ages 40–49 y with extremely dense breasts	Women ages 50–74 y	Women ages 40–49 y with a <1.3% 5-year risk of developing breast cancer
	or	or	or
	Women with a ≥6% 5-year risk (risk of an average BRCA carrier)	Women at a ≥1% 5-year risk of developing Estrogen Receptor breast cancer based on susceptibility Single Nucleotide Polymorphisms	Women aged 40–49 y with a ≥1.3% 5-year risk (risk of an average 50-year-old woman)
	or	or
	Women with a history of mantle radiation	Women in top 2.5th percentile of risk by 1-year age category
Screening recommendation	Annual mammogram+ Magnetic Resonance Imaging (MRI)	Annual mammogram*	Biennial mammogram†	No screening until age 50 y

^*If individual does not meet criteria for annual mammogram + MRI.

^†If individual does not meet criteria for annual mammogram or annual mammogram + MRI. The risk predictions are based on the Breast Cancer Surveillance Consortium risk prediction model together with a polygenic risk score.